Endocrine Abstracts

Introduction: Obesity is associated with reduced testosterone, and low testosterone induces weight gain. This study analysed the effects of normalization of serum testosterone in mainly elderly, hypogonadal men.Methods: Prospective registry study of 252 men (mean age 60.6±8.0 years), with testosterone levels between ≤ 3.5 ng/ml. They received parenteral testosterone undecanoate 1000 mg at day 1, week 6 and every 12 weeks thereafter for up to 6...

Diabetes contributes to 80% mortality in coronary heart disease (CHD). Hyperglycaemia antedates diabetes and is a late stage in the series of events leading to diabetes.Stress hyperglycaemia on admission with acute myocardial infarction (AMI) has been reported to have an increased risk of in-hospital mortality/morbidity.We conducted a retrospective study of all AMI admissions to coronary care unit over a six-month period to see th...

Introduction: Sertoli-leydig cell tumours are neoplasms of ovarian sex cord stromal cells and account for 0.5-2% of ovarian tumours with reported incidence <0.5 % of all ovarian tumours. These tumours usually manifest in women at younger age (in 75 % patients average age of onset <30). Majority of these tumours produce hormones and up to 80% of ovarian Sertoli-Leydig cell tumours can manifest with signs of virilization.Case report: 18 year old fe...

A 46 years old gentleman was referred by his GP to cardiology with 3 weeks history of bilateral leg swelling and rash associated with breathlessness and palpitations. He has no other past medical history to note. He smokes 20 cigarettes a day and works as a manager in a window installation company. He was started on diuretics and further investigations were arranged by cardiology. His symptoms persisted with worsening of skin rash. He was reviewed by GP again 1 month later. He...

Aim: To define a basal Cortisol threshold that could potentially predict the outcome of short synacthen test (SST) and thus reduce the need for performing SST in patients with low clinical probability for adrenal insufficiency.Methods: We analysed SSTs done at our hospital in non-critically ill general medical and endocrine patients, who had abnormal 0900 h Cortisol levels (n=110, male-45, female-65) between January 2016 to March 2016. The SST w...

Introduction: Thyrotropin-secreting adenomas are a rare cause of hyperthyroidism. Preferred treatment is pituitary neurosurgery.Case report: A 35 year old lady was first noted to have abnormal thyroid function when presenting with an AV-nodal re-entry tachycardia in 2011. She had tremors, sweating and irritability. FT4 was 35 pmol/l (10-20 pmol/l) with a non-suppressed TSH level of 7.5 U/l (02–6 U/l). Previous meningococcal meninigitis ag...

Objectives: Elderly men often show a concurrence of a decline of testosterone with features of the metabolic syndrome.Materials and methods: One hundred and twenty-two men of a mean age of 59.5±6.0 years, with baseline testosterone 5.9–12.1 nmol/l were treated with parenteral testosterone undecanoate for 42 months as the sole intervention.Results: Plasma testosterone rose from 9.3±1.7 to 18.7±2.1 nmol/l reaching...

Objectives: To investigate the safety of the administration of long-acting parenteral testosterone undecanoate (TU) to hypogonadal, mainly elderly men.Design and methods: One hundred and twenty-two men of a mean age of 59.5±6.0 years, with baseline testosterone 5.9–12.1 nmol/l were treated with parenteral TU. These 122 patients were followed for 42 months.Results: Plasma levels of testosterone rose from 9.3±1.7 to 18...

Diabetes and impaired glucose tolerance are associated with increased risk of cardiovascular diseases. Criteria for high risk populations that should be screened for diabetes needs be revising.Hospital admissions are stressful events and abnormally high random blood glucose levels are not acted upon appropriately.We studied 100 consecutive admissions to coronary care unit to assess the incidence of hyperglycaemia/diabetes on admiss...

Introduction: Paragangliomas are neuroendocrine tumours, usually found from the base of the skull to pelvis. They are extremely rare in the sellar and parasellar region which normally lacks paraganglion cells. We report a rare case of an incidental sellar paraganglioma.Case: A 66 years old female had progressive retinopathy and maculopathy of unclear cause since 2011. Lung nodules were seen on CT performed to exclude paraneoplastic retinopathy. 18F-FDG P...